Endocrine Abstracts

Introduction: Hirata Syndrome (SH) is a rare cause of autoimmune hypoglycemia, characterized by elevated circulating insulin levels without concomitant increase in C-peptide, anti-insulin antibodies positivity and pancreas alterations absence in patients never exposed to exogenous insulin. It is also known as insulin autoimmune syndrome (IAS) and is a relatively rare cause of spontaneous hypoglycemia. The syndrome was first described in 1970 by Yukimasa Hirata in Japan, the co...

Context: Thyrotoxicosis is the most common endocrine adverse event due totreatment with anti-PD1 and anti-PD-L1. The most common form is destructive thyrotoxicosis whereas persistent, supposedly autoimmune hyperthyroidism (Graves’ hyperthyroidism) is rare. The possible role of thyroid imaging (neck ultrasound and scintigraphy) in the differential diagnosis has never evaluated.Aim: To evaluate the usefulness of neck ultrasound and 99Tc- s...

PurposeObjective of this study was to assess the association between testosterone (T) levels and biochemical markers in a cohort of female patients admitted for SARS-CoV-2 infection in a respiratory intensive care unit (RICU).MethodsA consecutive series of 17 women affected by SARSCoV-2 pneumonia and recovered in the RICU of the Hospital of Mantua (Italy) were analyzed. Biochemical inflammatory markers as wel...

Introduction: An increase in dietary iodine uptake, from insufficient to borderline values, induces the unmasking of a hidden epitope on thyroglobulin (Tg). No data about the effect of an excessive iodine intake on the expression of Tg epitopes recognized by human TgAb are available.Objective: To compare the expression of TgAb epitopes in sera of Hashimoto’s thyroiditis (HT) patients from areas with adequate, slightly and markedly excessive iodine i...

Introduction: Incidental diagnosis of thyroid nodules has increased in recent years, leading to thyroid cancer diagnosis inflation. Nonetheless, mortality rate for thyroid malignancies remains very low, suggesting that its treatment is unlikely to affect the overall prognosis in the majority of cases. Several thyroid imaging scores have been proposed to reduce unnecessary invasive diagnostic procedures. Our aim was to verify the usefulness of the EU-TIRADS score on sparing thy...

Introduction: Xanthomas are defined as aggregates of lipid-laden histiocytes. They are generally present in superficial soft tissues such as skin and subcutis but can occasionally involve deep soft tissues. Xanthomas are classically associated with hyperlipidemia, that can be primary or secondary to numerous disorders such as diabetes. This case highlights an atypical manifestation of T2D.Case report: A 61-year-old women was referred to our endocrinology...

Introduction: Adrenal incidentalomas are a frequent finding (1.4-7.3% on abdominal CT) and increasingly common with age, obesity, diabetes and hypertension. When approaching adrenal masses, clinicians should exclude malignancy and hormonal hypersecretion. Black adrenal adenomas (BAA), first reported in 1938, are rare benign adrenocortical tumours with black/brown appearance, containing lipofuscin. Most are non-functional, rarely inducing hypercortisolism. We present a case of ...

Context: Vitamin D is a fat-soluble vitamin which requires the hydroxylation into 1,25-dihydroxyvitamin D (1,25-(OH)2D3) to be fully active. Vitamin D deficiency is a worldwide health problem associated to a wide range of acute and chronic diseases. On other hand, vitamin D supplementation has been proposed to reduced the risk of metabolic dysfunctions including obesity, type 2 diabetes and cardiovascular disease. Vitamin D interacts with the epigenetic m...

Introduction: There are few studies either hospital bases or population based in Africa and in Angola we also have the same situation regarding endocrinology data. With this paper, the Angolan Society of Endocrinology Diabetes and Metabolism (SAEDM), wants to contribute to the systematic and continued study of endocrine pathology in Angola.Objective: Study of the casuistic of endocrine pathology in ambulatory setting regarding the year 2015.<p class=...

Introduction: Diabetes Mellitus is a chronic disease that has serious effects on the morbi-mortality. Diabetes type 1 is less prevalent, representing 5–10% of the total cases. Data collected in Africa are scarce, and prevalence and incidence at sub - Saharan Africa are about 3-12/100,000 and 1.1–2.1/100,000 people, respectively. The Angolan reality is not known.Objective: To show the casuistic of diabetes type 1 obtained from the ambulatory con...